The Chicago White Sox and Miguel Vargas square off against Pete Crow-Armstrong and the Chicago Cubs on Saturday, in the second game of a three-game series at Wrigley Field. The Cubs average 1.4 home runs per game to rank third in MLB play with 64 total home runs. The White Sox rank 28th in Major League Baseball with just 34 home runs as a team.

The Chicago White Sox (14-30) visit the Chicago Cubs (25-19) to open a 3-game Crosstown Classic series Friday. First pitch from Wrigley Field is at 2:20 p.m. ET (MLB Network). Let's analyze BetMGM Sportsbook's MLB odds around the White Sox vs. Cubs odds and make our expert MLB picks and predictions for the best bets.